Reduced evolvability of Escherichia coli MDS42, an IS-less cellular chassis for molecular and synthetic biology applications

BACKGROUND: Evolvability is an intrinsic feature of all living cells. However, newly emerging, evolved features can be undesirable when genetic circuits, designed and fabricated by rational, synthetic biological approaches, are installed in the cell. Streamlined-genome E. coli MDS42 is free of mutat...

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Библиографические подробности
Главные авторы: Umenhoffer, Kinga, Fehér, Tamás, Balikó, Gabriella, Ayaydin, Ferhan, Pósfai, János, Blattner, Frederick R, Pósfai, György
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891674/
https://ncbi.nlm.nih.gov/pubmed/20492662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-9-38
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