Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor

We determined the crystal structure of a bifunctional group I intron splicing factor and homing endonuclease, termed the I-AniI maturase, in complex with its DNA target at 2.6 Å resolution. The structure demonstrates the remarkable structural conservation of the β-sheet DNA-binding motif between hig...

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Bolduc, Jill M., Spiegel, P. Clint, Chatterjee, Piyali, Brady, Kristina L., Downing, Maureen E., Caprara, Mark G., Waring, Richard B., Stoddard, Barry L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2003
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC289148/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14633971/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1109003
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