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Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments
Cytoskeletal protein phosphorylation is frequently altered in neuropathologic states but little is known about changes during normal aging. Here we report that declining protein phosphatase activity, rather than activation of kinases, underlies aging-related neurofilament hyperphosphorylation. Purif...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891331/ https://ncbi.nlm.nih.gov/pubmed/20031277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2009.12.001 |
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