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Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments

Cytoskeletal protein phosphorylation is frequently altered in neuropathologic states but little is known about changes during normal aging. Here we report that declining protein phosphatase activity, rather than activation of kinases, underlies aging-related neurofilament hyperphosphorylation. Purif...

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Detalhes bibliográficos
Main Authors: Veeranna, Yang, Dun-Sheng, Lee, Ju-Hyun, Vinod, K. Yaragudri, Stavrides, Philip, Amin, Niranjana D., Pant, Harish C., Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891331/
https://ncbi.nlm.nih.gov/pubmed/20031277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2009.12.001
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