Transient non-native hydrogen bonds promote activation of a signaling protein

Phosphorylation is one of the most commonly used signaling mechanisms in biology. However, the molecular transition pathways between inactive and active states are poorly understood. Here we quantitatively characterize the free-energy landscape of activation of the signaling protein Nitrogen regulat...

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Detalhes bibliográficos
Main Authors: Gardino, Alexandra K., Velos, Janice, Lei, Ming, Kivenson, Alexsandr, Liu, Ce Feng, Steindel, Phillip, Eisenmesser, Elan Z., Labeikovsky, Wladimir, Wolf-Watz, Magnus, Clarkson, Michael W., Kern, Dorothee
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891250/
https://ncbi.nlm.nih.gov/pubmed/20005804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.11.022
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