Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation and IL-17 production in the absence of SIV infection

Pigtail macaques (PTM) rapidly progress to AIDS after SIV infection. Given the strong association between HIV/SIV disease progression and microbial translocation and immune activation, we assessed whether high basal levels of immune activation and microbial translocation exist in PTM. We found that...

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Auteurs principaux: Klatt, Nichole R., Harris, Levelle D., Vinton, Carol L., Sung, Hannah, Briant, Judith A., Tabb, Brian, Morcock, David, McGinty, John W., Lifson, Jeffrey D., Lafont, Bernard A., Martin, Malcolm A., Levine, Alan D., Estes, Jacob D., Brenchley, Jason M.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891168/
https://ncbi.nlm.nih.gov/pubmed/20357762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2010.14
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