A recombinant sialidase fusion protein effectively inhibits human parainfluenza viral infection in vitro and in vivo

BACKGROUND: The first step in infection by human parainfluenza viruses (HPIVs) is binding to the surface of respiratory epithelial cells via interaction between viral receptor-binding molecules and sialic acid-containing receptors. DAS181, a recombinant sialidase protein containing the catalytic dom...

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Main Authors: Moscona, Anne, Porotto, Matteo, Palmer, Samantha, Tai, Caroline, Aschenbrenner, Lori, Triana-Baltzer, Gallen, Li, Qi-Xiang, Wurtman, David, Niewiesk, Stefan, Fang, Fang
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891144/
https://ncbi.nlm.nih.gov/pubmed/20533871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/653621
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