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Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-κB-deficient mice
NF-κB is a major regulator of innate and adaptive immunity. Neutrophilic granulocytes (neutrophils) constitutively express RelA/p65 (Rela), c-Rel (Crel) and p50 (Nfκb1), but not p52 (Nfκb2) subunits. We here describe Crel(−/−)Nfκb1(−/−)Rela(+/−) mice, that have the most severe genetic neutrophil NF-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891140/ https://ncbi.nlm.nih.gov/pubmed/20519647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000339 |
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