Selective apoptosis induction by the cancer chemopreventive agent N-(4-hydroxyphenyl)retinamide is achieved by modulating mitochondrial bioenergetics in premalignant and malignant human prostate epithelial cells

Prostate tumorigenesis is coupled with an early metabolic switch in transformed prostate epithelial cells that effectively increases their mitochondrial bioenergetic capacity. The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR) inhibits prostate cancer development in vivo, and triggers react...

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Bibliographic Details
Main Authors: Hail, Numsen, Chen, Ping, Kepa, Jadwiga J.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891029/
https://ncbi.nlm.nih.gov/pubmed/19421858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-009-0356-4
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