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Identification of Hedgehog Signaling Inhibitors with Relevant Human Exposure by Small Molecule Screening
In animal models, chemical disruption of the Hedgehog (Hh) signaling pathway during embryonic development causes severe birth defects including holoprosencephaly and cleft lip and palate. The exact etiological basis of correlate human birth defects remains uncertain but is likely multifactorial, inv...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891024/ https://ncbi.nlm.nih.gov/pubmed/20434536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2010.04.011 |
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