CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction

We hypothesized that a small molecule CXCR4 antagonist, AMD3100 (AMD), could augment the mobilization of bone marrow (BM)-derived endothelial progenitor cells (EPCs), thereby enhancing neovascularization and functional recovery after myocardial infarction. Single-dose AMD injection administered afte...

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Detalhes bibliográficos
Main Authors: Jujo, Kentaro, Hamada, Hiromichi, Iwakura, Atsushi, Thorne, Tina, Sekiguchi, Haruki, Clarke, Trevor, Ito, Aiko, Misener, Sol, Tanaka, Toshikazu, Klyachko, Ekaterina, Kobayashi, Koichi, Tongers, Jörn, Roncalli, Jérôme, Tsurumi, Yukio, Hagiwara, Nobuhisa, Losordo, Douglas W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890743/
https://ncbi.nlm.nih.gov/pubmed/20534467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914248107
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