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Cα-trace model of the transmembrane domain of human copper transporter 1, motion and functional implications

The trimeric human copper transporter 1 (hCTR1) is essential for copper uptake and is implicated in sensitivity to chemotherapy drugs. Using the cryoelectron microscopy (cryoEM) map of hCTR1 and evolutionary data, we constructed a Cα-trace model of the membrane region. The model structure, supported...

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Main Authors: Schushan, Maya, Barkan, Yariv, Haliloglu, Turkan, Ben-Tal, Nir
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890728/
https://ncbi.nlm.nih.gov/pubmed/20534491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914717107
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