Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies

HIV-1 R5 viruses vary widely in their capacity to infect primary macrophages. R5 macrophage-tropism is associated with an increased envelope:CD4 affinity that partly results from an increased exposure of CD4 contact residues on gp120 and allows the use of low levels of CD4 for infection. The selecti...

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Bibliographic Details
Main Authors: Richards, Kathryn H, Aasa-Chapman, Marlén MI, McKnight, Áine, Clapham, Paul R
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Short Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890664/
https://ncbi.nlm.nih.gov/pubmed/20507591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-48
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