Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion

RNA virus polymerases must initiate replicative RNA synthesis with extremely high accuracy to maintain their genome termini and to avoid generating defective genomes. For the single-stranded negative-sense RNA viruses, it is not known how this accuracy is achieved. To investigate this question, muta...

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Bibliographic Details
Main Authors: Noton, Sarah L., Cowton, Vanessa M., Zack, Chadene R., McGivern, David R., Fearns, Rachel
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890450/
https://ncbi.nlm.nih.gov/pubmed/20479224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913065107
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