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Signaling properties of a covalent modification cycle are altered by a downstream target

We used a model system of purified components to explore the effects of a downstream target on the signaling properties of a covalent modification cycle, an example of retroactivity. In the experimental system used, a bifunctional enzyme catalyzed the modification and demodification of its substrate...

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Autors principals: Ventura, Alejandra C., Jiang, Peng, Van Wassenhove, Lauren, Del Vecchio, Domitilla, Merajver, Sofia D., Ninfa, Alexander J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890436/
https://ncbi.nlm.nih.gov/pubmed/20479260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913815107
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