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Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.
In mammals, Up-frameshift proteins (UPFs) form a surveillance complex that interacts with the exon junction complex (EJC) to elicit nonsense-mediated mRNA decay (NMD). UPF3b is the component of the surveillance complex that bridges the interaction with the EJC. Here, we report the 3.4 Å resolution c...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890422/ https://ncbi.nlm.nih.gov/pubmed/20479275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000993107 |
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