Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

In mammals, Up-frameshift proteins (UPFs) form a surveillance complex that interacts with the exon junction complex (EJC) to elicit nonsense-mediated mRNA decay (NMD). UPF3b is the component of the surveillance complex that bridges the interaction with the EJC. Here, we report the 3.4 Å resolution c...

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Detalhes bibliográficos
Main Authors: Buchwald, Gretel, Ebert, Judith, Basquin, Claire, Sauliere, Jerome, Jayachandran, Uma, Bono, Fulvia, Le Hir, Hervé, Conti, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890422/
https://ncbi.nlm.nih.gov/pubmed/20479275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000993107
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