Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

Bone marrow injury is a major adverse side effect of radiation and chemotherapy. Attempts to limit such damage are warranted, but their success requires a better understanding of how radiation and anticancer drugs harm the bone marrow. Here, we report one pivotal role of the BH3-only protein Puma in...

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Bibliographic Details
Main Authors: Shao, Lijian, Sun, Yan, Zhang, Zhonghui, Feng, Wei, Gao, Yongxing, Cai, Zailong, Wang, Zack Z., Look, A. Thomas, Wu, Wen-Shu
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890171/
https://ncbi.nlm.nih.gov/pubmed/20360471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-248872
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