Transcriptional and Translational Dual-regulated Oncolytic Herpes Simplex Virus Type 1 for Targeting Prostate Tumors

The aim of this project was to demonstrate that an oncolytic herpes simplex virus type 1 (HSV-1) can replicate in a tissue- and tumor-specific fashion through both transcriptional (prostate-specific promoter, ARR(2)PB) and translational (5′-untranslated regions (5′UTRs) of rFGF-2) regulation of an e...

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Autores principales: Lee, Cleo YF, Bu, Luke XX, DeBenedetti, Arrigo, Williams, B Jill, Rennie, Paul S, Jia, William WG
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890095/
https://ncbi.nlm.nih.gov/pubmed/20179676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.26
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