Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop

BACKGROUND: The FUS-DDIT3 fusion oncogene encodes an abnormal transcription factor that has a causative role in the development of myxoid/round-cell liposarcomas (MLS/RCLS). We have previously identified FLT1 (VEGFR1) as a candidate downstream target gene of FUS-DDIT3. The aim of this study was to i...

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Hlavní autoři: Andersson, Mattias K, Göransson, Melker, Olofsson, Anita, Andersson, Carola, Åman, Pierre
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889895/
https://ncbi.nlm.nih.gov/pubmed/20515481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-249
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