Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF). However, understanding its pathogenesis has been hindered by lack of an animal model with characteristic features of CF. To overcome this problem, we recently generated pigs with targeted CFTR genes. We now report that,...

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Hlavní autoři: Stoltz, David A, Meyerholz, David K, Pezzulo, Alejandro A, Ramachandran, Shyam, Rogan, Mark P, Davis, Greg J, Hanfland, Robert A, Wohlford-Lenane, Chris, Dohrn, Cassie L, Bartlett, Jennifer A, Nelson, George A, Chang, Eugene H, Taft, Peter J, Ludwig, Paula S, Estin, Mira, Hornick, Emma E, Launspach, Janice L, Samuel, Melissa, Rokhlina, Tatiana, Karp, Philip H, Ostedgaard, Lynda S, Uc, Aliye, Starner, Timothy D, Horswill, Alexander R, Brogden, Kim A, Prather, Randall S, Richter, Sandra S, Shilyansky, Joel, McCray, Paul B, Zabner, Joseph, Welsh, Michael J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889616/
https://ncbi.nlm.nih.gov/pubmed/20427821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000928
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