Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus

OBJECTIVE: HMG-CoA reductase inhibitors have been shown to upregulate GTP cyclohydrolase I (GTPCH-I), the key enzyme for tetrahydrobiopterin de novo synthesis and to normalize tetrahydrobiopterin levels in hyperglycemic endothelial cells. We sought to determine whether in vivo treatment with the HMG...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wenzel, Philip, Daiber, Andreas, Oelze, Matthias, Brandt, Moritz, Closs, Ellen, Xu, Jian, Thum, Thomas, Bauersachs, Johann, Ertl, Georg, Zou, Ming-Hui, Förstermann, Ulrich, Müunzel, Thomas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2007
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889614/
https://ncbi.nlm.nih.gov/pubmed/18061195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2007.10.003
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