Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus

OBJECTIVE: HMG-CoA reductase inhibitors have been shown to upregulate GTP cyclohydrolase I (GTPCH-I), the key enzyme for tetrahydrobiopterin de novo synthesis and to normalize tetrahydrobiopterin levels in hyperglycemic endothelial cells. We sought to determine whether in vivo treatment with the HMG...

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Main Authors: Wenzel, Philip, Daiber, Andreas, Oelze, Matthias, Brandt, Moritz, Closs, Ellen, Xu, Jian, Thum, Thomas, Bauersachs, Johann, Ertl, Georg, Zou, Ming-Hui, Förstermann, Ulrich, Müunzel, Thomas
Format: Artigo
Language:Inglês
Published: 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889614/
https://ncbi.nlm.nih.gov/pubmed/18061195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2007.10.003
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