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CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation
Hsp104 is a ring-forming AAA+ machine that recognizes both aggregated proteins and prion-fibrils as substrates and, together with the Hsp70 system, remodels substrates in an ATP-dependent manner. Whereas the ability to disaggregate proteins is dependent on the Hsp104 M-domain, the location of the M-...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889573/ https://ncbi.nlm.nih.gov/pubmed/20404203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003572107 |
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