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The Positively Charged Surface of Herpes Simplex Virus UL42 Mediates DNA Binding

Herpes simplex virus DNA polymerase is a heterodimer composed of UL30, a catalytic subunit, and UL42, a processivity subunit. Mutations that decrease DNA binding by UL42 decrease long chain DNA synthesis by the polymerase. The crystal structure of UL42 bound to the C terminus of UL30 revealed an ext...

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Bibliografiske detaljer
Main Authors: Komazin-Meredith, Gloria, Santos, Webster L., Filman, David J., Hogle, James M., Verdine, Gregory L., Coen, Donald M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889492/
https://ncbi.nlm.nih.gov/pubmed/18178550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708691200
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