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Increased activity of indoleamine 2,3-dioxygenase in serum from acutely infected dengue patients linked to gamma interferon antiviral function

The depletion of l-tryptophan (L-Trp) has been associated with the inhibition of growth of micro-organisms and also has profound effects on T cell proliferation and immune tolerance. The enzyme indoleamine 2,3-dioxygenase (IDO) catalyses the rate-limiting step in the catabolic pathway of L-Trp. Gene...

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Detalhes bibliográficos
Main Authors: Becerra, Aniuska, Warke, Rajas V., Xhaja, Kris, Evans, Barbara, Evans, James, Martin, Katherine, de Bosch, Norma, Rothman, Alan L., Bosch, Irene
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889436/
https://ncbi.nlm.nih.gov/pubmed/19264674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.004416-0
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