Caricamento...
Insights into protein folding mechanisms from large scale analysis of mutational effects
Protein folding mechanisms are probed experimentally using single-point mutant perturbations. The relative effects on the folding (ϕ-values) and unfolding (1 - ϕ) rates are used to infer the detailed structure of the transition-state ensemble (TSE). Here we analyze kinetic data on > 800 mutations...
Salvato in:
| Autori principali: | , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2010
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889297/ https://ncbi.nlm.nih.gov/pubmed/20418505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000988107 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|