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Insights into protein folding mechanisms from large scale analysis of mutational effects
Protein folding mechanisms are probed experimentally using single-point mutant perturbations. The relative effects on the folding (ϕ-values) and unfolding (1 - ϕ) rates are used to infer the detailed structure of the transition-state ensemble (TSE). Here we analyze kinetic data on > 800 mutations...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889297/ https://ncbi.nlm.nih.gov/pubmed/20418505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000988107 |
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