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Silibinin can induce differentiation as well as enhance vitamin D(3) -induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors
Induction of terminal differentiation is a conceptually attractive approach for the therapy of neoplastic diseases. Although vitamin D derivatives (deltanoids) can induce differentiation of AML cells in vitro, so far deltanoids have not been successfully brought to the clinic, due to the likelihood...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889217/ https://ncbi.nlm.nih.gov/pubmed/19866452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hon.929 |
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