17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer’s prevention

Insulin-degrading enzyme (IDE), an enzyme that primarily degrades insulin, has recently been demonstrated to play a significant role in the catabolism of amyloid β (Aβ) protein in the brain. Reduced IDE expression and/or activity have been associated with the etiology and development of Alzheimer’s...

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Bibliographic Details
Main Authors: Zhao, Liqin, Yao, Jia, Mao, Zisu, Chen, Shuhua, Wang, Yan, Brinton, Roberta Diaz
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889185/
https://ncbi.nlm.nih.gov/pubmed/20053478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2009.12.010
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