Kv4.2 channels tagged in the S1–S2 loop for alpha-bungarotoxin binding provide a new tool for studies of channel expression and localization

We report the first successful insertion of an engineered, high-affinity α-bungarotoxin (Bgtx) binding site into a voltage-gated ion channel, Kv4.2, using a short, intra-protein embedded sequence (GGWRYYESSLEPYPDGG), derived from a previously described mimotope peptide, HAP. A major benefit to this...

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Detaylı Bibliyografya
Asıl Yazarlar: Moise, Leonard, Liu, Jing, Pryazhnikov, Evgeny, Khiroug, Leonard, Jeromin, Andreas, Hawrot, Edward
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888848/
https://ncbi.nlm.nih.gov/pubmed/20139708
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