14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) Surrogates Containing Epoxide Bioisosteres: Influence upon Vascular Relaxation and Soluble Epoxide Hydrolase Inhibition

All-cis-14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a labile, vasodilatory eicosanoid generated from arachidonic acid by cytochrome P450 epoxygenases. A series of robust, partially saturated analogs containing epoxide bioisosteres were synthesized and evaluated for relaxation of precontrac...

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Hauptverfasser: Falck, J. R., Kodela, Ravinder, Manne, Rajkumar, Atcha, Krishnam Raju, Puli, Narender, Dubasi, Narsimhaswamy, Manthati, Vijay L., Capdevila, Jorge H., Yi, Xiu-Yu, Goldman, Daniel H., Morisseau, Christophe, Hammock, Bruce D., Campbell, William B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888647/
https://ncbi.nlm.nih.gov/pubmed/19653681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900634w
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