Caffeine Prevents Transcription Inhibition and P-TEFb/7SK Dissociation Following UV-Induced DNA Damage

BACKGROUND: The mechanisms by which DNA damage triggers suppression of transcription of a large number of genes are poorly understood. DNA damage rapidly induces a release of the positive transcription elongation factor b (P-TEFb) from the large inactive multisubunit 7SK snRNP complex. P-TEFb is req...

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Hauptverfasser: Napolitano, Giuliana, Amente, Stefano, Castiglia, Virginia, Gargano, Barbara, Ruda, Vera, Darzacq, Xavier, Bensaude, Olivier, Majello, Barbara, Lania, Luigi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888590/
https://ncbi.nlm.nih.gov/pubmed/20574533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011245
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