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Conformational Determinants of Phosphotyrosine Peptides Complexed with the Src SH2 Domain

The inhibition of specific SH2 domain mediated protein-protein interactions as an effective chemotherapeutic approach in the treatment of diseases remains a challenge. That different conformations of peptide-ligands are preferred by different SH2 domains is an underappreciated observation from the s...

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Autors principals: Nachman, Joseph, Gish, Gerry, Virag, Cristina, Pawson, Tony, Pomès, Régis, Pai, Emil
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888578/
https://ncbi.nlm.nih.gov/pubmed/20574521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011215
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