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Conformational Determinants of Phosphotyrosine Peptides Complexed with the Src SH2 Domain
The inhibition of specific SH2 domain mediated protein-protein interactions as an effective chemotherapeutic approach in the treatment of diseases remains a challenge. That different conformations of peptide-ligands are preferred by different SH2 domains is an underappreciated observation from the s...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2888578/ https://ncbi.nlm.nih.gov/pubmed/20574521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011215 |
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