Small CGG repeat expansion alleles of FMR1 gene are associated with parkinsonism

Fragile X associated tremor/ataxia (FXTAS) affects older males carrying premutation, that is, expansions of the CGG repeat (in the 55-200 range), in the FMR1 gene. The neurological changes are linked to the excessive FMR1 mRNA, becoming toxic through a ‘gain-of-function’. Since elevated levels of th...

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Main Authors: Loesch, Danuta Z, Khaniani, Mahmoud S, Slater, Howard R, Rubio, Justin P., Bui, Quang M, Kotschet, Kate, D’Souza, Wendy, Venn, Alison, Kalitsis, Paul, Choo, Andy KH, Burgess, Trent, Johnson, Laura, Evans, Andrew, Horne, Malcolm
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888465/
https://ncbi.nlm.nih.gov/pubmed/19796183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1399-0004.2009.01275.x
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