p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-α-converting Enzyme/ADAM17

During the development of the sympathetic nervous system, the p75 neurotrophin receptor (p75NTR) has a dual function: promoting survival together with TrkA in response to NGF, but inducing cell death upon binding pro or mature brain-derived neurotrophic factor (BDNF). Apoptotic signaling through p75...

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Detalhes bibliográficos
Main Authors: Kenchappa, Rajappa S., Tep, Chhavy, Korade, Zeljka, Urra, Soledad, Bronfman, Francisca C., Yoon, Sung Ok, Carter, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888447/
https://ncbi.nlm.nih.gov/pubmed/20421303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.082834
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