Xenin-25 Potentiates Glucose-dependent Insulinotropic Polypeptide Action via a Novel Cholinergic Relay Mechanism

The intestinal peptides GLP-1 and GIP potentiate glucose-mediated insulin release. Agents that increase GLP-1 action are effective therapies in type 2 diabetes mellitus (T2DM). However, GIP action is blunted in T2DM, and GIP-based therapies have not been developed. Thus, it is important to increase...

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Autors principals: Wice, Burton M., Wang, Songyan, Crimmins, Dan L., Diggs-Andrews, Kelly A., Althage, Matthew C., Ford, Eric L., Tran, Hung, Ohlendorf, Matthew, Griest, Terry A., Wang, Qiuling, Fisher, Simon J., Ladenson, Jack H., Polonsky, Kenneth S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888395/
https://ncbi.nlm.nih.gov/pubmed/20421298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129304
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