Transforming Growth Factor β Promotes Complexes between Smad Proteins and the CCCTC-binding Factor on the H19 Imprinting Control Region Chromatin

Whether signal transduction pathways regulate epigenetic states in response to environmental cues remains poorly understood. We demonstrate here that Smad3, signaling downstream of transforming growth factor β, interacts with the zinc finger domain of CCCTC-binding factor (CTCF), a nuclear protein k...

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Hlavní autoři: Bergström, Rosita, Savary, Katia, Morén, Anita, Guibert, Sylvain, Heldin, Carl-Henrik, Ohlsson, Rolf, Moustakas, Aristidis
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888383/
https://ncbi.nlm.nih.gov/pubmed/20427289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.088385
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