Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation

SARS coronavirus (SARS-CoV) is known to efficiently suppress the induction of antiviral type I interferons (IFN-α/β) in non-lymphatic cells through inhibition of the transcription factor IRF-3. Plasmacytoid dendritic cells, in contrast, respond to infection with production of high levels of IFNs. He...

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Detalhes bibliográficos
Main Authors: Kuri, Thomas, Zhang, Xiaonan, Habjan, Matthias, Martínez-Sobrido, Luis, García-Sastre, Adolfo, Yuan, Zhenghong, Weber, Friedemann
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2009
Assuntos:
Animal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888313/
https://ncbi.nlm.nih.gov/pubmed/19625461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.013599-0
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