Herpes simplex virus type 1 latency-associated transcript inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is expressed abundantly in latently infected sensory neurons. LAT-deletion-mutant virus strains have reduced-reactivation phenotypes in small animal models of infection, demonstrating that LAT plays an important role in the...

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Bibliographic Details
Main Authors: Li, Sumin, Carpenter, Dale, Hsiang, Chinhui, Wechsler, Steven L., Jones, Clinton
Format: Artigo
Language:Inglês
Published: Society for General Microbiology 2010
Subjects:
Animal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888161/
https://ncbi.nlm.nih.gov/pubmed/19955563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.015719-0
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