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A Novel, Single Algorithm Approach to Predict Acenocoumarol Dose Based on CYP2C9 and VKORC1 Allele Variants

The identification of CYP2C9 and VKORC1 genes has strongly stimulated the research on pharmacogenetics of coumarins in the last decade. We assessed the combined influence of CYP2C9 *2 and *3, and VKORC1 c.-1639G>A, 497C>G, and 1173C>T variants, on acenocoumarol dosage using a novel algorith...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Verde, Zoraida, Ruiz, Jonatan R., Santiago, Catalina, Valle, Beatriz, Bandrés, Fernando, Calvo, Elpidio, Lucía, Alejandro, Gallego, Félix Gómez
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887839/
https://ncbi.nlm.nih.gov/pubmed/20585445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011210
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