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Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis

Interleukin 2 (IL-2)- and IL-10-knockout mice develop spontaneous colitis under conventional but not germ-free conditions, suggesting that commensal bacteria play an important role in the pathogenesis of colitis. However, interactions between commensal bacteria and colonic epithelial cells have not...

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Detalhes bibliográficos
Main Authors: Ohkusa, Toshifumi, Yoshida, Tsutomu, Sato, Nobuhiro, Watanabe, Sumio, Tajiri, Hisao, Okayasu, Isao
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887547/
https://ncbi.nlm.nih.gov/pubmed/19369513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jmm.0.005801-0
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