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Progesterone Withdrawal Reduces Paired-Pulse Inhibition in Rat Hippocampus: Dependence on GABA(A) Receptor α4 Subunit Upregulation
Withdrawal from the endogenous steroid progesterone (P) after chronic administration increases anxiety and seizure susceptibility via declining levels of its potent GABA-modulatory metabolite 3α-OH-5α-pregnan-20-one (3α,5α-THP). This 3α,5α-THP withdrawal also results in a decreased decay time consta...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2887349/ https://ncbi.nlm.nih.gov/pubmed/12522171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00195.2002 |
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