Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure

The central melanocortin system plays a key role in the regulation of food intake and energy homeostasis. We investigated whether genetic or pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in mice and rats with heart failure. Permanent ligation of the left corona...

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Bibliographic Details
Main Authors: Scarlett, Jarrad M, Bowe, Darren D, Zhu, Xinxia, Batra, Ayesha K, Grant, Wilmon F, Marks, Daniel L
Format: Artigo
Language:Inglês
Published: BioScientifica 2010
Subjects:
Regular papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887273/
https://ncbi.nlm.nih.gov/pubmed/20371568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-09-0397
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