Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines

PURPOSE: Oxaliplatin effect in the treatment of colorectal cancer is improved upon combination with thymidylate synthase (TS) inhibitors. Pemetrexed is polyglutamated by the folylpolyglutamate synthase (FPGS) and blocks folate metabolism and DNA synthesis by inhibiting TS, dihydrofolate reductase (D...

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Bibliografiska uppgifter
Huvudupphovsmän: Nannizzi, Sara, Veal, Gareth J., Giovannetti, Elisa, Mey, Valentina, Ricciardi, Simona, Ottley, Christopher J., Del Tacca, Mario, Danesi, Romano
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer-Verlag 2009
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886085/
https://ncbi.nlm.nih.gov/pubmed/20020129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1195-2
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