The siRNA targeted to mdr1b and mdr1a mRNAs in vivo sensitizes murine lymphosarcoma to chemotherapy

BACKGROUND: One of the main obstacles for successful cancer polychemotherapy is multiple drug resistance phenotype (MDR) acquired by tumor cells. Currently, RNA interference represents a perspective strategy to overcome MDR via silencing the genes involved in development of this deleterious phenotyp...

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Main Authors: Patutina, Olga A, Mironova, Nadezda L, Popova, Nelly A, Kaledin, Vasily I, Nikolin, Valery P, Vlassov, Valentin V, Zenkova, Marina A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886043/
https://ncbi.nlm.nih.gov/pubmed/20470373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-204
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