Gene expression profiling in frataxin deficient mice: Microarray evidence for significant expression changes without detectable neurodegeneration

Friedreich’s ataxia (FRDA) is caused by reduction of frataxin levels to 5–35%. To better understand the biochemical sequelae of frataxin reduction, in absence of the confounding effects of neurodegeneration, we studied the gene expression profile of a mouse model expressing 25–36% of the normal frat...

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Bibliographic Details
Main Authors: Coppola, Giovanni, Choi, Sang-Hyun, Santos, Manuela M., Miranda, Carlos J., Tentler, Dmitri, Wexler, Eric M., Pandolfo, Massimo, Geschwind, Daniel H.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886035/
https://ncbi.nlm.nih.gov/pubmed/16442805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2005.11.014
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