Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60 dependent transcriptional regulation and apoptotic pathway

The TIP60 tumor suppressor is a histone acetyltransferase involved in transcriptional regulation, checkpoint activation, and p53-directed pro-apoptotic pathways. We report that Human Papilloma Virus (HPV) E6 destabilizes TIP60 both in vivo and in vitro. TIP60 binds to the HPV major early promoter an...

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Bibliografiska uppgifter
Huvudupphovsmän: Jha, Sudhakar, Pol, Scott Vande, Banerjee, Nilam Sanjib, Dutta, Arun Brendan, Chow, Louise T., Dutta, Anindya
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886028/
https://ncbi.nlm.nih.gov/pubmed/20542002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.020
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