Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes

In mammalian zygotes, the 5-methyl-cytosine (5mC) content of paternal chromosomes is rapidly changed by a yet unknown but presumably active enzymatic mechanism. Here, we describe the developmental dynamics and parental asymmetries of DNA methylation in relation to the presence of DNA strand breaks,...

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Bibliographic Details
Main Authors: Wossidlo, Mark, Arand, Julia, Sebastiano, Vittorio, Lepikhov, Konstantin, Boiani, Michele, Reinhardt, Richard, Schöler, Hans, Walter, Jörn
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885932/
https://ncbi.nlm.nih.gov/pubmed/20442707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.80
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