Kidney Injury Molecule-1 Outperforms Traditional Biomarkers of Kidney Injury in Multi-site Preclinical Biomarker Qualification Studies

Kidney toxicity accounts for a significant percentage of morbidity and drug candidate failure. Serum creatinine (SCr) and blood urea nitrogen (BUN) have been used to monitor kidney dysfunction for over a century but these markers are insensitive and non-specific. In multi-site preclinical rat toxico...

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Main Authors: Vaidya, Vishal S., Ozer, Josef S., Frank, Dieterle, Collings, Fitz B., Ramirez, Victoria, Troth, Sean, Muniappa, Nagaraja, Thudium, Douglas, Gerhold, David, Holder, Daniel J., Bobadilla, Norma A., Marrer, Estelle, Perentes, Elias, Cordier, André, Vonderscher, Jacky, Maurer, Gérard, Goering, Peter L., Sistare, Frank D., Bonventre, Joseph V.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885849/
https://ncbi.nlm.nih.gov/pubmed/20458318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1623
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