Kidney Injury Molecule-1 Outperforms Traditional Biomarkers of Kidney Injury in Multi-site Preclinical Biomarker Qualification Studies

Kidney toxicity accounts for a significant percentage of morbidity and drug candidate failure. Serum creatinine (SCr) and blood urea nitrogen (BUN) have been used to monitor kidney dysfunction for over a century but these markers are insensitive and non-specific. In multi-site preclinical rat toxico...

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Main Authors: Vaidya, Vishal S., Ozer, Josef S., Frank, Dieterle, Collings, Fitz B., Ramirez, Victoria, Troth, Sean, Muniappa, Nagaraja, Thudium, Douglas, Gerhold, David, Holder, Daniel J., Bobadilla, Norma A., Marrer, Estelle, Perentes, Elias, Cordier, André, Vonderscher, Jacky, Maurer, Gérard, Goering, Peter L., Sistare, Frank D., Bonventre, Joseph V.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885849/
https://ncbi.nlm.nih.gov/pubmed/20458318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1623
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