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Inflammation and endoplasmic reticulum stress in obesity and diabetes

Obesity is associated with chronic low-grade inflammation. Inflammatory signals interfere with insulin action and disrupt metabolic homeostasis. The c-Jun N-terminal kinase (JNK) has been identified as a central mediator of insulin resistance. Recent studies showed that in obesity compromising endop...

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Библиографические подробности
Главный автор: Hotamisligil, GS
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885768/
https://ncbi.nlm.nih.gov/pubmed/19136991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ijo.2008.238
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